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Targeting lipid biosynthesis pathways for hepatitis B virus cure.
Hyrina A, Burdette D, Song Z, Ramirez R, Okesli-Armlovich A, Vijayakumar A, Bates J, Trevaskis JL, Fletcher SP, Lee WA, Holdorf MM. Hyrina A, et al. Among authors: holdorf mm. PLoS One. 2022 Aug 4;17(8):e0270273. doi: 10.1371/journal.pone.0270273. eCollection 2022. PLoS One. 2022. PMID: 35925919 Free PMC article.
Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Gorsuch CL, Nemec P, Yu M, Xu S, Han D, Smith J, Lape J, van Buuren N, Ramirez R, Muench RC, Holdorf MM, Feierbach B, Falls G, Holt J, Shoop W, Sevigny E, Karriker F, Brown RV, Joshi A, Goodwin T, Tam YK, Lin PJC, Semple SC, Leatherbury N, Delaney Iv WE, Jantz D, Rhoden Smith A. Gorsuch CL, et al. Among authors: holdorf mm. Mol Ther. 2022 Sep 7;30(9):2909-2922. doi: 10.1016/j.ymthe.2022.05.013. Epub 2022 May 16. Mol Ther. 2022. PMID: 35581938 Free PMC article.
Structure of an ETHE1-like protein from Arabidopsis thaliana.
McCoy JG, Bingman CA, Bitto E, Holdorf MM, Makaroff CA, Phillips GN Jr. McCoy JG, et al. Among authors: holdorf mm. Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):964-70. doi: 10.1107/S0907444906020592. Epub 2006 Aug 19. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 16929096
Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection.
Burdette D, Hyrina A, Song Z, Beran RK, Cheung T, Gilmore S, Kobayashi T, Li L, Liu Y, Niedziela-Majka A, Medley J, Mehra U, Morganelli P, Novikov N, Niu C, Tam D, Tang J, Wang J, Yue Q, Fletcher SP, Holdorf MM, Delaney WE 4th, Feierbach B, Lazerwith S. Burdette D, et al. Among authors: holdorf mm. Antimicrob Agents Chemother. 2023 Jan 24;67(1):e0134822. doi: 10.1128/aac.01348-22. Epub 2022 Dec 15. Antimicrob Agents Chemother. 2023. PMID: 36519892 Free PMC article.